Genetic Architecture in Autoimmunity: Shaping the Response to Stimulation

This seminar will review the current insights into the heritable genetic variation in human immune system molecules that influence our risk for developing autoimmune disease. Antibody formation as part of the humoral immune response and the interaction of these antibodies with their cognate receptors are central to immune host defense. Mechanisms that enhance our response to vaccines also increase the risk of autoimmune disease.