GABA Neurons in Schizophrenia: From Circuits to Cells to Molecular Regulation

A new paradigm for understanding how the brain’s inhibitory neurons (GABAergic cells) dysfunction in neuropsychiatric disorders is evolving. Dr. Benes will discuss the evidence from human postmortem studies for a GABAergic deficit in schizophrenia. She will also explore how rodent and other models can be used to validate this hypothesis. Her principal focus will be on the regulation of GABAergic neurons by the amygdala and a regulatory network that involves genetic and epigenetic regulation.