Building and Using In-Vivo Microscopes to Understand Brain Function and Physiology

Imaging the living brain at a cellular level presents many challenges. While genetic techniques now allow fluorescent and functional labeling of brain cells, as well as optical control of cells, in-vivo microscopy techniques must overcome scattering and the limited penetration of light into living tissues, while imaging at high enough speeds to capture events such as neuronal firing. In her seminar, Dr. Hillman will describe a variety of different techniques that she has developed for imaging the in-vivo brain, and demonstrate their application to understanding the mechanisms that regulate local blood flow changes in the living brain.