Gene Targeting into the 21st Century: Modeling Human Disease from Cancer to Neuropsychiatric Disorders

Gene Targeting into the 21st Century: Modeling Human Disease from Cancer to Neuropsychiatric Disorders

November 12, 2015, 5:30 p.m. to 6:30 p.m.

Mario Capecchi, PhD

Nobel Prize Laureate in Physiology or Medicine, 2007 Distinguished Professor of Human Genetics and of Biology Howard Hughes Medical Institute Investigator University of Utah School of Medicine Salt Lake City, Utah

Virginia Tech Carilion Research Institute, M106

Gene targeting allows designed modifications of any chosen gene in the mouse. Using this technology allows the generation of mouse models for human disease. The models, once verified to recapitulate the human disease, can be used to understand the disease at the molecular, cellular, and organismic level not possible in humans. Once an understanding is reached, the model can in turn be used as a platform for developing new therapeutic protocols for the management of the disease.

Nobel Prize Laureate Mario Capecchi will provide examples of gene targeting developed from his own laboratory involving childhood cancers and neuropsychiatric disorders.