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In Person Lecture: Human Cardiac Metabolism

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Zoltan Arany, M.D., Ph.D.

Samuel Bellet Professor of Cardiology
Co-Director, Cardiovascular Division
Institute for Diabetes, Obesity & Metabolism
Perelman School of Medicine
University of Pennsylvania

Timothy A. Johnson Medical Scholar Lecture: Human Cardiac Metabolism

About this Seminar

Heart failure is understood to be in part a metabolic disorder, but most of our understanding of cardiac metabolism stems from pre-clinical models. Dr. Arnay and his lab therefore leveraged modern mass spectrometry and metabolomics to probe cardiac metabolism in human health and disease in two contexts: (1) arteriovenous differences in plasma metabolite concentrations across the cardiac microvasculature in 120 patients undergoing elective procedures requiring placement of a coronary sinus catheter, and (2) tissue samples from excised hearts from patients undergoing transplantation for non-ischemic dilated cardiomyopathy or from organ donors with normal cardiac function. From the former, the lab calculated flux of hundreds metabolites in and out of the heart in health and disease, while from the latter researchers gathered mechanistic insight into metabolic alterations in heart failure.

Additional Details

This is a free event hosted by the Fralin Biomedical Research Institute and the Virginia Tech Carilion School of Medicine. The Timothy A. Johnson Medical Scholar Lecture Series hosts clinician scientists who are exploring frontiers of medicine. These lectures are principally intended for Virginia Tech Carilion School of Medicine students and Virginia Tech students in the Translational Biology, Medicine, and Health graduate program. Virginia Tech and Carilion Clinic faculty, staff, and students may also attend.

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