In Person Lecture: Human Cardiac Metabolism
Zoltan Arany, M.D., Ph.D.
Samuel Bellet Professor of Cardiology
Co-Director, Cardiovascular Division
Institute for Diabetes, Obesity & Metabolism
Perelman School of Medicine
University of Pennsylvania
Timothy A. Johnson Medical Scholar Lecture: Human Cardiac Metabolism
About this Seminar
Heart failure is understood to be in part a metabolic disorder, but most of our understanding of cardiac metabolism stems from pre-clinical models. Dr. Arnay and his lab therefore leveraged modern mass spectrometry and metabolomics to probe cardiac metabolism in human health and disease in two contexts: (1) arteriovenous differences in plasma metabolite concentrations across the cardiac microvasculature in 120 patients undergoing elective procedures requiring placement of a coronary sinus catheter, and (2) tissue samples from excised hearts from patients undergoing transplantation for non-ischemic dilated cardiomyopathy or from organ donors with normal cardiac function. From the former, the lab calculated flux of hundreds metabolites in and out of the heart in health and disease, while from the latter researchers gathered mechanistic insight into metabolic alterations in heart failure.
Additional Details
This is a free event hosted by the Fralin Biomedical Research Institute and the Virginia Tech Carilion School of Medicine. The Timothy A. Johnson Medical Scholar Lecture Series hosts clinician scientists who are exploring frontiers of medicine. These lectures are principally intended for Virginia Tech Carilion School of Medicine students and Virginia Tech students in the Translational Biology, Medicine, and Health graduate program. Virginia Tech and Carilion Clinic faculty, staff, and students may also attend.
You May Also Be Interested In...
-
Home Item
How Big Med Drives Rising Healthcare Costs and What to Do About It , homeFeb. 20, 2025, 5:30 p.m. (Reception at 5 p.m.) | Vivian Ho, Ph.D., James A. Baker III Institute Chair in Health Economics, Baker Institute for Public Policy, Rice University | Maury Strauss Distinguished Public Lecture
-
Home Item
Addictive Nicotine and Stress Induce Convergent Mechanisms That Increase Alcohol Self‐administration , homeFeb. 21, 2025, 11:00 a.m. | John Dani, Ph.D., Professor of Neurological Sciences, Chair, Department of Neuroscience, Scientific Director, UPENN, CNS Consortium, Perlman School of Medicine, University of Pennsylvania | Co-Sponsored by the Fralin Biomedical Research Institute Center for Human Neuroscience Research
-
Home Item
Exploring the Functional Role of Gene Variation in Nicotine and Alcohol Abuse , homeFeb. 21, 2025, 1 p.m. | Mariella De Biasi, Ph.D., Professor, Director, Program for Cholingeric Mechanisms in Addiction, Perlman School of Medicine, University of Pennsylvania | Co-Sponsored by the Fralin Biomedical Research Institute Center for Human Neuroscience Research
-
Home Item
The Relationship between Mitochondrial Function and Heart Failure , homeFeb. 28, 2025, 11:00 a.m. | Rong Tian, M.D., Ph.D., Professor, Department of Anesthesiology and Bioengineering, University of Washington | Co-Sponsored by the Fralin Biomedical Research Institute Center for Vascular and Heart Research
-
Home Item
Suicide by Firearm in the United States: A Collaborative Path for Prevention , homeMarch 6, 2025, 5:30 p.m. (Reception at 5 p.m.) | Marian Betz, M.D., M.P.H. Professor, Departments of Epidemiology and Emergency Medicine, Deputy Director, Injury & Violence Prevention Center, University of Colorado School of Public Health; Member, National Academy of Medicine | Maury Strauss Distinguished Public Lecture
-
Home Item
Thinking the Right Thoughts , homeMarch 7, 2025, 11:00 a.m. | Nathaniel Daw, Ph.D., Professor, Computational and Theoretical Neuroscience, Department of Psychology, Princeton University | Co-Sponsored by the Fralin Biomedical Research Institute Center for Human Neuroscience Research