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Stressed Out and Hyperactive: The Role of Astroglia in Degenerative CNS Diseases

  • When July 15 , 2015, 11 a.m. to noon
  • Who Cherie Eileen Bond, PhD

    Assistant Professor of Biology, Ferrum College, Ferrum, Virginia

  • Where Virginia Tech Carilion Research Institute, R1059
    2 Riverside Circle, Roanoke, VA 24016

Through calcium signaling cascades, astroglia control the normal and abnormal neuronal environment in developmental and degenerative processes, regulating gene expression, differentiation, and growth, as well as programmed cell death. In addition, astrocytes are essential components of the neurovascular unit, regulating the local cerebral blood flow and maintaining the integrity of the blood-brain barrier through interaction between their end-foot processes and endothelial cells in brain capillaries.

Dysfunction of the neurovascular unit has been implicated in a number of degenerative nervous system diseases, such as Alzheimer’s and Parkinson’s, as well as in CNS complications from systemic disorders such as diabetes, chronic heart disease, and sepsis. Interestingly, individuals who survive cardiac arrest and systemic sepsis often demonstrate significant impairments in cognitive abilities, particularly in spatial learning and memory, as well as a predisposition to severe depression, suggesting that certain areas of the brain are highly vulnerable to hypoxia-induced oxidative damage and disruption of the blood-brain barrier. It has been proposed that astroglial inflammatory responses may underlie many of these degenerative processes.

Cherie Eileen Bond, PhD

Cherie Eileen Bond, PhD

Dr. Bond received her doctorate in medical and molecular genetics and neurobiology in 2000 from the Indiana School of Medicine in Indianapolis. After a decade of postdoctoral research in neuroscience at The Rockefeller University, UCLA, the University of Bath, and Oxford University, for four years Dr. Bond served as assistant director of the Molecular Biology Core Facility and research assistant professor at the Quillen College of Medicine at East Tennessee State University, where she also taught clinical neuroscience to medical, physical therapy, and biomedical sciences graduate students. Dr. Bond teaches molecular and cell biology, genetics, biotechnology, and bioethics at Ferrum College in Virginia.

Additional details

This is a free event. The host is Michael Friedlander, PhD.

Map and parking

This map shows where the Virginia Tech Carilion Research Institute is located in Roanoke, VA at 2 Riverside Circle.

Parking is available in the surface lot or in the adjacent parking garage.

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